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  1. Antman-Passig, M., Shefi, O. Engineering Oriented Scaffolds for Directing Neuronal Regeneration. Virtual Prototyping & Bio Manufacturing in Medical Applications, (pp. 125–152) (2021).


  1. Haimov-Talmoud, E., Rosenberg, M., Arshavsky-Graham, S., Varon, E., Shefi, O., & Segal, E. Biolistic Delivery of Photosensitizer-Loaded Porous Si Carriers for Localized Photodynamic Therapy. Adv. Mater. Technol., (2023) 2300877.
  2. Levenberg, D. R., Varon, E., Indech, G., Ben Uliel, T., Geri, L., Sharoni, A., Shefi. O. A Streptavidin-biotin combined with magnetic actuators for remote neuronal guidance, J.Biol Eng (2023) 17, 40.
  3. Indech, G., Geri, L., Mordechai, C., YBen Moshe, Y., Mastai, M., Shefi, O,. Sharoni, A. Controlled synthesis of multifunctional dome-shaped micro- and nano-structures via a robust physical route for biological applications. J. Mater. Chem. B (2023).
  4. Varon, E., Blumrosen, G,. Shefi, O. A predictive model for personalization of nanotechnology-based phototherapy in cancer treatment. Front. Oncol. (2023), 12:1037419.
  5. Plen, R., Smith, A., Blum, O., Aloni, O., Locker, U., Shapira, Z., Margel, S., Shefi, O. Bioengineering 3D Neural Networks Using Magnetic Manipulations. Adv. Funct. Mater. (2022) 32, 2204925.
  6. Varon, E. Blumrosen, G. Sinvani, M. Haimov, E. Polani, S.Natan, M. Shoval, I. Jacob, A. Atkins, A. Zitoun, D. Shefi, O. An Engineered Nanocomplex with Photodynamic and Photothermal Synergistic Properties for cancer treatment. Int. J.Mol.Sci.(2022),23,2286.
  7. Kumar, R., Rauti, R., Scaini, D., Antman-Passig, M., Meshulam, O., Naveh, D., Ballerini, L., Shefi, O. Graphene-Based Nanomaterials for Neuroengineering: Recent Advances and Future Prospective, Adv. Funct. Mater (2021) 2104887
  8. Indech, G., Plen, R., Levenberg, D., Vardi, N., Marcus, M., Smith, A., Margel, S., Shefi, O., Sharoni, A. Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons, JoVE, (2021).
  9. Xu, W., Jambhulkar, S., Ravichandran, D., Zhu, Y.,Kakarla, M., Nian, Q., Azeredo, B., Chen, X., Jin, K., Vernon, B., G. Lott, D., L. Cornella, J., Shefi, O., Miquelard-Garnier, G., Yang, Y., Song, K. 3D Printing-Enabled Nanoparticle Alignment: A Review of Mechanisms and Applications, Small (2021), 2100817.
  10. Xu, W., Jambhulkar, S., Zhu, Y., Ravichandran, D., Kakarla, M., Vernon, B., G. Lott, D., L. Cornella, J., Shefi, O., Miquelard-Garnier, G., Yang, Y., Song, K. 3D printing for polymer/particle-based processing: A review, Compos.B. Eng. (2021),109102.
  11. Antman‐Passig, M., Giron, J., Karni, M., Motiei, M., Schori,H., Shefi, O. Magnetic Assembly of a Multifunctional Guidance Conduit for Peripheral Nerve Repair. Adv.Funct.Mater.(2021), 31, 2010837.
  12. Marcus, M., Indech, G., Vardi, N., Levy, I., Smith, A., Margel, S., Shefi, O., Sharoni, A. Magnetic Organization of Neural Networks via Micro-Patterned Devices, Adv. Mater. Interfaces (2020),7, 2000055.
  13. Tiwari, A., Kumar, R., Shefi, O., Randhawa, J. Fluorescent Mantle Carbon Coated Core-Shell SPIONs for Neuroengineering Applications, ACS Appl.BioMater.(2020), 3,4665−4673.
  14. Cohen, S., Richter-Levin, A., Shefi, O. Brief Electrical Stimulation triggers an effective regeneration of Leech CNS, eNeuro (2020), 7, 1–15.
  15. Hacohen, A., Jessel, H.R., Richter Levin, A., Shefi, O. Patterning of Particles and Live Cells at Single Cell Resolution, Micromachines (2020), 11, 505.
  16. Ofer, N., Shefi, O. & Yaari, G. Axonal Tree Morphology and Signal Propagation Dynamics Improve Interneuron Classification, Neuroinform (2020), 18:581–590.
  17. Cohen, S., Sazan, H., Kenigsberg, A., Schori, H., Piperno, S., Shpaisman, H., Shefi, O. Large-scale acoustic-driven neuronal patterning and directed outgrowth. Sci. Rep. (2020),10, 4932.
  18. Haimov-Talmoud E., Harel, Y., Schori, H., Motiei, M., Atkins, A., Popovtzer, R., Lellouche, J.P., Shefi, O. Magnetic Targeting of MTHPC To Improve the Selectivity and Efficiency of Photodynamic Therapy. ACS Appl. Mater. Interfaces (2019), 11, 49.
  19. Zilony‐Hanin, N., Rosenberg, M., Richman, M., Yehuda, R., Schori, H., Motiei, M., Rahimipour, S., Groisman, A., Segal, E. & Shefi, O. Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain. Small,(2019), 15, 1904203.
  20. Kumar, V. B., Kumar, R., Friedman, O., Golan, Y., Gedanken, A., & Shefi, O. (2019). One‐Pot Hydrothermal Synthesis of Elements (B, N, P)‐Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells. ChemistrySelect, 4(14), 4222-4232.
  21. Kumar, R., Kumar, V. B., Marcus, M., Gedanken, A., & Shefi, O. . Element (B, N, P) doped carbon dots interaction with neural cells: promising results and future prospective. SPIE, (2019) ,10892.
  22. Baranes, K., Hibsh, D., Cohen, S., Yamin, T., Efroni, S., Sharoni, A. & Shefi, O. (2019). Comparing transcriptome profiles of neurons interfacing adjacent cells and nano-patterned substrates reveal fundamental neuronal interactions. Nano Letters, doi: 10.1021/acs.nanolett.8b03879
  23. Rosenberg, M., Zilony, N., Shefi, O., & Segal, E. (2019). Designing Porous Silicon Films as Carriers of Nerve Growth Factor. Journal of Visualized Experiments, (143). doi:10.3791/58982
  24. Kumar V.B., Kumar, R., Gedanken, A. & Shefi, O. (2018) Fluorescent Metal-Doped Carbon Dots for Neuronal Manipulations. Ultrasonics Sonochemistry.
  25. Marcus, M., Smith, A., Maswadeh, A., Shemesh, Z., Zak, I., Motiei, M., … Shefi, O. (2018). Magnetic Targeting of Growth Factors Using Iron Oxide Nanoparticles. Nanomaterials, 8(9), 707.
  26. Ewing, A., Choi, I.S., Green, W., & Shefi, O. (2018). Frontiers in Neurochemistry, ChemPhysChem.
  27. Kumar-Yadav, S., Feigelson, S.W., Roncato, F., Antman-Passig, M., Shefi, O., Lammerding, J., & Alon, R. (2018). Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers, Journal of Leukocyte Biology.
  28. Kumar, V., Marcus, M., Porat, Z., Shani, L., Yeshurun, Y., Felner, I., Shefi, O., & Gedanken, A. (2018). Ultrafine Highly Magnetic Fluorescent γ-Fe2O3/NCD Nanocomposites for Neuronal Manipulations. ACS Omega.
  29. Haimov, E., Weitman, H., Polan, S., Schori, H., Zitoun, D., and Shefi, O (2018). meso-Tetrahydroxyphenylchlorin-Conjugated Gold Nanoparticles as a Tool To Improve Photodynamic Therapy. ACS Applied Materials & Interfaces.
  30. Nissan, I., Schori, H., Kumar, V.B., Antman-Passig, M., Shefi O., & Gedanken, A. (2017). Topographical Impact of Silver Nanolines on the Morphology of Neuronal SH-SY5Y Cells, Journal of Materials Chemistry B.
  31. Ofer, N., Shefi, O., & Yaari, G. (2017). Branching morphology determines signal propagation dynamics in neurons, Scientific reports, 7.
  32. Nissan, I., Kumar, V. B., Porat, Z. E., Makovec, D., Shefi, O., & Gedanken, A. (2017). Sonochemically-fabricated Ga@ C-dots@ Ga nanoparticle-aided neural growth. Journal of Materials Chemistry B, 5(7), 1371-1379.
  33. Marcus, M., Baranes, K., Park, M., Choi, I. S., Kang, K., & Shefi, O. (2017). Interactions of Neurons with Physical Environments. Advanced Healthcare Materials.
  34. Zilony, N., Rosenberg, M., Holtzman, L., Schori, H., Shefi, O., & Segal, E. (2017). Prolonged controlled delivery of nerve growth factor using porous silicon nanostructures. Journal of Controlled Release, 257, 51-59.
  35. Antman-Passig, M., Levy, S., Gartenberg, C., Schori, H., & Shefi, O. (2017). Mechanically Oriented 3D Collagen Hydrogel for Directing Neurite Growth. Tissue Engineering Part A, 23(9-10), 403-414.
  36. Marcus, M., Karni, M., Baranes, K., Levy, I., Alon, N., Margel, S., & Shefi, O. (2016). Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations. Journal of nanobiotechnology, 14(1), 37.
  37. Even, D. Y., Kedmi, A., Basch-Barzilay, S., Ideses, D., Tikotzki, R., Shir-Shapira, H., Shefi, O. & Juven-Gershon, T. (2016). Engineered Promoters for Potent Transient Overexpression. PloS one, 11(2), e0148918.
  38. Nissan, I., Schori, H., Lipovsky, A., Alon, N., Gedanken, A., & Shefi, O. (2016). Effect of different densities of silver nanoparticles on neuronal growth. Journal of Nanoparticle Research, 18(8), 221.
  39. Antman-Passig, M., & Shefi, O. (2016). Remote magnetic orientation of 3D collagen hydrogels for directed neuronal regeneration. Nano letters, 16(4), 2567-2573.
  40. Ilovitsh, A., Polak, P., Zalevsky, Z., & Shefi, O. (2016). Selective inactivation of enzymes conjugated to nanoparticles using tuned laser illumination. Cytometry Part A.
  41. Nissan, I., Schori, H., Lipovsky, A., Alon, N., Gedanken, A., & Shefi, O. (2016). Effect of different densities of silver nanoparticles on neuronal growth. Journal of Nanoparticle Research, 18(8), 221.
  42. Ofer, N., & Shefi, O. (2016). Axonal geometry as a tool for modulating firing patterns. Applied Mathematical Modelling, 40(4), 3175-3184.
  43. Baranes, K., Shevach, M., Shefi, O., & Dvir, T. (2015). Gold nanoparticle-decorated scaffolds promote neuronal differentiation and maturation. Nano letters, 16(5), 2916-2920.
  44. Alon, N., Havdala, T., Skaat, H., Baranes, K., Marcus, M., Levy, I., ... & Shefi, O. (2015). Magnetic micro-device for manipulating PC12 cell migration and organization. Lab on a Chip, 15(9), 2030-2036.
  45. Hibsh, D., Schori, H., Efroni, S., & Shefi, O. (2015). De novo transcriptome assembly databases for the central nervous system of the medicinal leech. Scientific data, 2.
  46. Polak, P., & Shefi, O. (2015). Nanometric agents in the service of neuroscience: manipulation of neuronal growth and activity using nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 11(6), 1467-1479.
  47. Schwartz, S., Fixler, D., Popovtzer, R., & Shefi, O. (2015). Fluorescence life‐time imaging and steady state polarization for examining binding of fluorophores to gold nanoparticles. Journal of biophotonics, 8(11-12), 944-951.
  48. Alon, N., Duadi, H., Cohen, O., Samet, T., Zilony, N., Schori, H., Shefi, O., & Zalevsky, Z. (2015). Promotion of neural sprouting using low-level green light-emitting diode phototherapy. Journal of biomedical optics, 20(2), 020502-020502.
  49. Marcus, M., Skaat, H., Alon, N., Margel, S., & Shefi, O. (2015). NGF-conjugated iron oxide nanoparticles promote differentiation and outgrowth of PC12 cells. Nanoscale, 7(3), 1058-1066.
  50. Baranes, K., Moshe, H., Alon, N., Schwartz, S., & Shefi, O. (2014). Neuronal growth on L-and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity. ACS chemical neuroscience, 5(5), 370-376.
  51. Alon, N., Miroshnikov, Y., Perkas, N., Nissan, I., Gedanken, A., & Shefi, O. (2014). Substrates coated with silver nanoparticles as a neuronal regenerative material. International journal of nanomedicine, 9(Suppl 1), 23.
  52. Hibsh, D., Schori, H., Efroni, S., & Shefi, O. (2013). Spatial regulation dominates gene function in the ganglia chain. Bioinformatics, 30(3), 310-316.
  53. Karni, M., Zidon, D., Polak, P., Zalevsky, Z., & Shefi, O. (2013). Thermal degradation of DNA. DNA and cell biology, 32(6), 298-301.
  54. Zilony, N., Tzur-Balter, A., Segal, E., & Shefi, O. (2013). Bombarding cancer: biolistic delivery of therapeutics using porous Si carriers. Scientific reports, 3.
  55. Polak, P., Zalevsky, Z., & Shefi, O. (2013). Gold nanoparticles-based biosensing of single nucleotide DNA mutations. International journal of biological macromolecules, 59, 134-137.
  56. Baranes, K., Chejanovsky, N., Alon, N., Sharoni, A., & Shefi, O. (2012). Topographic cues of nano‐scale height direct neuronal growth pattern. Biotechnology and bioengineering, 109(7), 1791-1797.
  57. Baranes, K., Kollmar, D., Chejanovsky, N., Sharoni, A., & Shefi, O. (2012). Interactions of neurons with topographic nano cues affect branching morphology mimicking neuron–neuron interactions. Journal of molecular histology, 43(4), 437-447.
  58. Shefi, O., Simonnet, C., Groisman, A., & Macagno, E. R. (2008). Localized RNAi and ectopic gene expression in the medicinal leech. Journal of visualized experiments: JoVE, (14).
  59. Shefi, O., Simonnet, C., Baker, M. W., Glass, J. R., Macagno, E. R., & Groisman, A. (2006). Microtargeted gene silencing and ectopic expression in live embryos using biolistic delivery with a pneumatic capillary gun. Journal of Neuroscience, 26(23), 6119-6123.
  60. Ayali, A., Fuchs, E., Zilberstein, Y., Robinson, A., Shefi, O., Hulata, E., ... & Ben‐Jacob, E. (2004). Contextual regularity and complexity of neuronal activity: From stand‐alone cultures to task‐performing animals. Complexity, 9(6), 25-32.
  61. Shefi, O., Golebowicz, S., Ben‐Jacob, E., & Ayali, A. (2005). A two‐phase growth strategy in cultured neuronal networks as reflected by the distribution of neurite branching angles. Developmental Neurobiology, 62(3), 361-368.
  62. Shefi, O., Harel, A., Chklovskii, D. B., Ben-Jacob, E., & Ayali, A. (2004). Biophysical constraints on neuronal branching. Neurocomputing, 58, 487-495.
  63. Shefi, O., Golding, I., Segev, R., Ben-Jacob, E., & Ayali, A. (2002). Morphological characterization of in vitro neuronal networks. Physical Review E, 66(2), 021905.
  64. Shefi, O., Ben-Jacob, E., & Ayali, A. (2002). Growth morphology of two-dimensional insect neural networks. Neurocomputing, 44, 635-643.
  65. Shefi, O., Davidson, S., Maayan, A., & Akselrod, S. (1998). The effect of thermal stimulation on the heart-rate variability in neonates. Early human development, 52(1), 49-66.
  66. Davidson, S., Reina, N., Shefi, O., Hai-Tov, U., & Akselrod, S. (1997). Spectral analysis of heart rate fluctuations and optimum thermal management for low birth weight infants. Medical and Biological Engineering and Computing, 35(6), 619.


  1. O. Ophir, O. Shefi and O. Lindenbaum. Neuronal Cell Type Classification Using Locally Sparse Networks, IEEE ICASSPW (2023), pp. 1-5,
  2. Alon, N., Miroshnikov, Y., Perkas, N., Nissan, I., Gedanken, A., & Shefi, O. (2014). Substrates coated with silver nanoparticles as a neuronal regenerative material. International journal of nanomedicine, 9(Suppl 1), 23.
  3. Tzur-Balter, A., Zilony, N., Shefi, O., & Segal, E. (2013, December). Bombarding Cancer: Biolistic Delivery of Therapeutics using Porous Si Carriers. In PSST 2014 Home Page.
  4. Ofer, N. & Shefi, O. (2013). Neuronal electrical activity patterns depend on the axon morphology-analysing the Hodgkin Huxley cable model. Journal of molecular neuroscience, 51, S85-S86.
  5. M Marcus, H Skaat, S Margel, O Shefi, Enhancement of neuronal growth and differentiation by the conjugation of beta-NGF to maghemite nanoparticles, JOURNAL OF MOLECULAR NEUROSCIENCE, 51 (S78), 2013.
  6. K Baranes, N Chejanovsky, N Zilony, A Sharoni, O Shefi, Neurons growing atop topographic nano-cues mimic neuron-neuron interactions, JOURNAL OF MOLECULAR NEUROSCIENCE 51 (S16), 2013.
  7. Ofer, N., & Shefi, O. (2013). Neuronal morphology as an instrument for information coding: studying the influence of axonal radius and branching points. BMC Neuroscience, 14(1), P357.
  8. Alon, N., Miroshnikov, Y., Perkas, N., Nissan, I., Gedanken, A., & Shefi, O. (2013). Silver nanoparticles promote neuronal growth. Procedia Engineering, 59, 25-29.
  9. N Ofer, O Shefi, Studying current stimuli and morphological modifications as instruments to code information, JOURNAL OF MOLECULAR NEUROSCIENCE, 48 (S87) 2012.
  10. Y Hakuk, Y Keller, O Shefi, Unsupervised segmentation of neuronal images via superpixels, JOURNAL OF MOLECULAR NEUROSCIENCE, 48 (S49-S50), 2012.
  11. K Baranes, N Chejanovsky, N Geva, A Sharoni, O Shefi, Nano-scale topographic cues direct neuronal growth, JOURNAL OF MOLECULAR NEUROSCIENCE, 48 (S11), 2012.

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